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Journal of Nutrition Research
An official journal of IAPEN India association


Journal of Nutrition Research

Year: 2023, Volume: 11, Issue: 2, Pages: 69-77

Original Article

Predicting Survival Outcomes at Five Years Following Administration of Omega-3 Long-Chain Fatty Acids in People Living with Squamous Cell Carcinoma of the Head and Neck

Received Date:30 May 2023, Accepted Date:01 July 2023, Published Date:12 August 2023


There is a paucity of research on longer-term outcomes following oral nutrition supplementation (ONS) in patients with cancer. An observational analysis on mortality and survival rates were conducted in patients with head and neck squamous cell carcinoma (HNSCC) that received cancer treatment ONS plus 2 g of eicosapentaenoic-acid (EPA) versus standard treatment (EN). Twenty-six participants were available (81.3% of the original cohort [n=32]) in the ONS-EPA 2 g and 24 (75% of original cohort [n=32]) in the ONS-standard groups. Mortality at five years was 50% in the ONS-EPA 2 g and 58.3% in the ONS-standard group but with longer survival time in the ONS-EPA 2 g than the ONS-standard group (35 versus 18 months, respectively). A trend toward a longer survival time five years was observed in participants who received ONS with a high EPA content compared to those who received standard-formula ONS. Results may represent a possible long-term benefit of using high EPA supplementation during active cancer treatment to address malnutrition and positively influence clinical outcomes.

Keywords: Nutritional supplementation, Eicosapentaenoic acid, Head and neck squamous cell carcinoma, 5­year mortality


  1. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patientsClinical Nutrition2017;36(1):1148. Available from: https://doi.org/10.1016/j.clnu.2016.07.015
  2. Weimann A, Braga M, Carli F, Higashiguchi T, Hübner M, Klek S, et al. ESPEN guideline: Clinical nutrition in surgeryClinical Nutrition2017;36(3):623650. Available from: https://doi.org/10.1016/j.clnu.2017.02.013
  3. Thompson KL, Elliott L, Fuchs-Tarlovsky V, Levin RM, Voss AC, Piemonte T. Oncology Evidence-Based Nutrition Practice Guideline for AdultsJournal of the Academy of Nutrition and Dietetics2017;117(2):297310. Available from: https://doi.org/10.1016/j.jand.2016.05.010
  4. Gorjao R, Santos CMMD, Serdan TDA, Diniz VLS, Alba-Loureiro TC, Cury-Boaventura MF, et al. New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acidsPharmacology & Therapeutics2019;196:117134. Available from: https://doi.org/10.1016/j.pharmthera.2018.12.001
  5. Shirai Y, Okugawa Y, Hishida A, Ogawa A, Okamoto K, Shintani M, et al. Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexiaScientific Reports2017;7(4826):19. Available from: https://doi.org/10.1038/s41598-017-05278-0
  6. Turcott JG, Juárez-Hernández E, Sánchez-Lara K, Flores-Estrada D, Zatarain-Barrón ZL, Arrieta O. Baseline Dysgeusia in Chemotherapy-Naïve Non-Small Cell Lung Cancer Patients: Association with Nutrition and Quality of LifeNutrition and Cancer2020;72(2):194201. Available from: https://doi.org/10.1080/01635581.2019.1633362
  7. Blarigan ELV, Fuchs CS, Niedzwiecki D, Ye X, Zhang S, Song M, et al. Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance) Cancer Epidemiology, Biomarkers & Prevention2018;27(4):438445. Available from: https://doi.org/10.1158/1055-9965.EPI-17-0689
  8. Solís-Martínez O, Plasa-Carvalho V, Phillips-Sixtos G, Trujillo-Cabrera Y, Hernández-Cuellar A, Queipo-García GE, et al. Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in MexicoNutrition and Cancer2018;70(4):663670. Available from: https://doi.org/10.1080/01635581.2018.1460678
  9. Garlini LM, Alves FD, Ceretta LB, Perry IS, Souza GC, Clausell NO. Phase angle and mortality: a systematic reviewEuropean Journal of Clinical Nutrition2019;73:495508. Available from: https://doi.org/10.1038/s41430-018-0159-1
  10. Kumar S, Dutt A, Hemraj S, Bhat S, Manipadybhima B. Phase angle measurement in healthy human subjects through bio-impedance analysisIranian Journal of Basic Medical Sciences2012;15(6):11801184. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646229/pdf/IJBMS-15-1180.pdf
  11. Taha HM, Rozek LS, Chen X, Li Z, Zarins KR, Slade AN, et al. Risk of Disease Recurrence and Mortality Varies by Type of Fat Consumed before Cancer Treatment in a Longitudinal Cohort of Head and Neck Squamous Cell Carcinoma PatientsThe Journal of Nutrition2022;152(5):12981305. Available from: https://doi.org/10.1093/jn/nxac032
  12. Groot RHMd, Emmett R, Meyer BJ. Non-dietary factors associated with 3 long-chain PUFA levels in humans – a systematic literature reviewBritish Journal of Nutrition2019;121(7):793808. Available from: https://doi.org/10.1017/S0007114519000138


© This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Published By India Association for Parenteral and Enteral Nutrition (IAPEN)


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