Nonalcoholic fatty liver disease - Non-invasive markers of fibrosis or liver biopsy for determining liver fibrosis

Parveen Malhotra; Vani Malhotra; Naveen Malhotra; Ajay Chugh; Abhisekh; Yogesh Sanwariya

doi:10.55289/jnutres/v6i1.1

Article

Nonalcoholic fatty liver disease - Non-invasive markers of fibrosis or liver biopsy for determining liver fibrosis

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Journal of Nutrition Research

DOI: 10.55289/jnutres/v6i1.1

Year: 2018, Volume: 6, Issue: 1, Pages: 100-106

Applied Clinical Nutrition Research

Nonalcoholic fatty liver disease - Non-invasive markers of fibrosis or liver biopsy for determining liver fibrosis

Parveen Malhotra*, Vani Malhotra, Naveen Malhotra, Ajay Chugh, Abhisekh, Yogesh Sanwariya

Department of Medical Gastroenterology, Medicine, Gynae. & Obstetrics, Anaesthesiology, PGIMS Rohtak – 124001, Haryana

*Corresponding Author
Email: [email protected]

Received Date:20 February 2018, Accepted Date:31 March 2018, Published Date:31 March 2018

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease & liver transplantation and its incidence is increasing even in Asian countries. The gold standard for assessing hepatic fibrosis is liver histology but due to its limitations, noninvasive tests to assess hepatic fibrosis which can be used as alternative to liver biopsy have been developed. In a cross-sectional study, 25 diagnosed NAFLD patients underwent detailed laboratory investigations including the specific non-invasive markers of fibrosis namely, Haptoglobin, Alpha-2 macroglobulin, Apolipoprotein- A1 levels and Insulin Resistance was calculated by Homeostasis Model Assessment (HOMA), then patients were subjected to liver biopsy. Out of 25 patients, 19(76%) were male and 6(24%) were females. Nine patients (36%) were diabetic and 21 (84%) were dyslipidemiac. Metabolic syndrome was present in 18(72%), body mass index was increased in 22 patients and waist hip ratio was altered in 22 patients (88%). Using SPSS 10, p value was significant (p= 0.04) for correlation between steatosis and waist/hip ratio and HOMA-IR with inflammation and fibrosis (p=0.03) but non-invasive markers were not significant in predicting hepatic fibrosis on histology.

Keywords: Non-alcoholic fatty liver disease, Liver fibrosis, Liver biopsy, Diabetes Mellitus, Metabolic Syndrome